This was an east-west route connecting Richmond Exchange and South Vancouver running primarily on Cambie Road. Service ran daily every hour, increasing to every 30 minutes during peak hours.
Eastbound trips departed Richmond Exchange heading north on No. 3 Road, east on Cambie Road, north on Viking Way, west on Bridgeport Road, and north on Knight Street across the Knight Street Bridge, taking the SE Marine Drive exit to Knight & SE Marine.
Westbound trips departed from Knight Street & SE Marine Drive heading west on SE Marine, south on Knight Street and across the Knight Street Bridge, then took the Bridgeport Road exit and went east on Bridgeport, south on Viking Way, west on Cambie Road, and south on No. 3 Road to Richmond Exchange.
July 1976 - Service introduced as 74 Cambie Road, running between Sexsmith Loop and Knight Street & SE Marine Drive, replacing significant portions of the 69 No. Five Road–Cambie. Peak hour trips went via Viking Way and Bridgeport Road instead of Knight Street
August 1977 - Service renumbered from 74 Cambie Road to 421 Cambie Road. Relocation of central bus exchange in Richmond from Sexsmith Loop to Richmond Centre results in the western terminus being revised to Richmond Centre[1]
May 1984 - Destination sign simplification: Service renamed from 421 Cambie Road to 421 Cambie Road/Richmond Exchange[2]
January 1990 - Service temporarily rerouted in both directions between Cambie & Jacombs and Marine Drive terminus via Jacombs, Bathgate, Sweden, Bridgeport, Knight Street due to the construction of the Cambie Road overpass across Knight Street; shuttle bus ran from Bridgeport & Sweden to connect with missed portions of the route on Viking Way[3]
December 1990 - Service revised to go via Viking Way for all trips instead of during peak hours only following the completion of the Cambie Road overpass and closure of access to Knight Street from Cambie Road[4]
August 2001 - Service discontinued and replaced by the 405 Cambie/Five Road;[5] service change deferred from April due to transit strike[6]